Retatrutide

Name: Buy Retatrutide | Triple GIP/GLP-1/Glucagon Agonist Research Peptide
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Buy Retatrutide, a triple GIP, GLP-1 & glucagon receptor agonist for metabolic research. High purity. Ideal for obesity & diabetes mechanism studies. Shop now.

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Retatrutide (LY3437943) – Triple Hormone Receptor Agonist Research Peptide – Buy Retatrutide Online

Retatrutide (LY3437943) – Triple GIP/GLP-1/Glucagon Receptor Agonist

Retatrutide (LY3437943) is a first-in-class, unimolecular triple hormone receptor agonist that simultaneously targets the glucose-dependent insulinotropic polypeptide (GIP) receptor, glucagon-like peptide-1 (GLP-1) receptor, and glucagon (GCG) receptor . Unlike semaglutide which solely activates GLP-1R, and tirzepatide which activates both GLP-1R and GIPR, retatrutide adds glucagon receptor agonism to drive energy expenditure through thermogenesis . Compared to corresponding endogenous hormones, retatrutide is more potent at GIPR by a factor of 8.9, and less potent at GCGR and GLP-1R by factors of 0.3 and 0.4, respectively . This research-grade peptide is strictly for laboratory investigation and not intended for human or animal use.

Key Factual Details

Attribute	Detail
Chemical Name	L-Serinamide, L-tyrosyl-2-methylalanyl-L-glutaminylglycyl-L-threonyl-L-phenylalanyl-L-threonyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-2-methyl-L-leucyl-L-leucyl-L-α-aspartyl-L-lysyl-N6-[N-(19-carboxy-1-oxononadecyl)-L-γ-glutamyl-2-[2-(2-aminoethoxy)ethoxy]acetyl]-L-lysyl-L-alanyl-L-glutaminyl-2-methylalanyl-L-alanyl-L-phenylalanyl-L-isoleucyl-L-α-glutamyl-L-tyrosyl-L-leucyl-L-leucyl-L-α-glutamylglycylglycyl-L-prolyl-L-seryl-L-serylglycyl-L-alanyl-L-prolyl-L-prolyl-L-prolyl-L-serinamide
Molecular Formula	C₂₂₁H₃₄₂N₄₆O₆₈
Molecular Weight	4731.34 g/mol (4.731 kDa)
CAS Number	2381089-83-2
Sequence	Tyr-{Aib}-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-{α-Me-Leu}-Leu-Asp-Lys-{diacid-C20-gamma-Glu-(AEEA)-Lys}-Ala-Gln-{Aib}-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
Synonyms	LY3437943
Purity	≥98% (HPLC verified)
Classification	Triple hormone receptor agonist (GIPR, GLP-1R, GCGR)

Mechanism of Action & Research Applications

Triple Receptor Agonism

Retatrutide’s unique mechanism combines three complementary pathways :

GIP Receptor (GIPR): Enhances glucose-dependent insulin secretion and promotes satiety signaling
GLP-1 Receptor (GLP-1R): Delays gastric emptying, increases insulin secretion, suppresses appetite
Glucagon Receptor (GCGR): Drives energy expenditure through thermogenesis, increases fat oxidation

Structural Mechanism

Cryo-electron microscopy studies reveal that retatrutide adopts a single continuous alpha-helix that penetrates the receptor transmembrane domain via its N-terminal segment (residues 1–13), while its C-terminal segment interacts with the extracellular domain . The triple agonism is achieved through a combination of common interactions with conserved residues (including salt bridges with E⁶·⁵³ᵇ and E/D⁷·⁴²ᵇ, stacking interactions with tryptophan residues, and hydrogen bonding networks) and receptor-specific contacts that accommodate structural variations in each receptor .

Research Applications:

Metabolic Research: Investigating multi-target incretin pathways for obesity and type 2 diabetes
Energy Expenditure Studies: Examining GCGR-mediated thermogenesis mechanisms
Cardiovascular-Kidney-Metabolic (CKM) Research: Exploring systemic hemodynamic effects
Hepatic Steatosis Models: Investigating liver fat reduction pathways
Receptor Interaction Studies: Characterizing GIPR, GLP-1R, and GCGR binding dynamics

Research Parameters

All dosages are for in-vitro and preclinical research use only and are not intended for human consumption.

Clinical Research Dosing (Phase 2 Data) :

Dose	Weight Loss at 24 Weeks	Weight Loss at 48 Weeks
4 mg (once weekly)	~15.2% fat mass reduction	Not reported
8 mg (once weekly)	~26.1% fat mass reduction	Not reported
12 mg (once weekly)	~17.5% total body weight	24.2% total body weight

Key Clinical Observations :

63% of participants achieved ≥20% total body weight loss at 12 mg dose
23.2% reduction in fat mass confirmed by DXA (dual-energy X-ray absorptiometry) scans
Absolute HbA1c reduction of 2.02% in type 2 diabetes patients
27% of diabetic participants reached normoglycemia (HbA1c < 5.7%)
82.4% relative reduction in hepatic fat; normalization in 86% of patients
Systolic blood pressure reduction: 8.79 mm Hg

Storage:

Store lyophilized powder at -20°C
Protect from light and moisture

Order Retatrutide Today – Request a quote for your metabolic research project. Available in various pack sizes with COA. Contact our sales team for bulk pricing and custom synthesis inquiries.